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Analysis on Research and Development Progress of 1. Ultrasonic Cleaning Technology

(1) Technology development process

Ultrasonic cleaning is a cleaning technology that uses ultrasonic energy to clean, which first appeared in the 20th century.

30 s. It has been widely studied and applied for decades. In recent years, the theoretical research of ultrasonic cleaning is also more in-depth and thorough, and the mechanism of ultrasonic cleaning is constantly refined, and there are some computer simulation methods for cavitation sound field. The core components of ultrasonic cleaning))) The ultrasonic transducer is also more in-depth in theoretical research, perfecting the characteristics of the transducer under various loads. With the development and improvement of ultrasonic cleaning theory and technology, its application is expanding, and ultrasonic cleaning has been widely used in all aspects of industry. In our country, with the rapid development of industry, especially the development of manufacturing industry and the increase of environmental protection requirements for the production process, the application of ultrasonic cleaning also has new characteristics.
(2) Progress in research and development of cleaning equipment

Clean-in-place (CIP) and sterilization-in-place (SIP) refer to the cleaning and sterilization of the system or equipment at the original installation position without disassembly and movement. Compared with manual cleaning, online cleaning is simpler, more efficient, and saves labor, thereby reducing costs. At present, online cleaning technology has been widely used in pharmaceutical and biotechnology processes.
Automatic CIP cleaning technology came into being

On-line cleaning technology is an ideal equipment and pipeline cleaning method, including equipment, pipeline, operation process, cleaning agent formula, automatic control and regulatory requirements of a set of technical systems. It can clean dirt without dismantling or moving equipment and pipelines.

With the improvement of equipment requirements in the pharmaceutical industry and the development of science and technology, the automatic CIP cleaning system came into being. The automatic CIP cleaning system is composed of alkali tank, acid tank, hot water tank, various pipelines and pneumatic valves, pressure transmitter, conductivity meter, platinum thermal resistance and control system. It uses centrifugal pump to transport cleaning liquid in material pipelines and equipment for forced circulation to achieve the purpose of cleaning. Therefore, there is no need to disassemble the pipeline equipment, which can improve the utilization rate of the equipment and reduce the labor intensity of the workers.
At present, China's online cleaning technology is still relatively weak, some pharmaceutical equipment only has one or several spray head structure for cleaning, and some parts need to be disassembled and washed. Such CIP technology obviously cannot provide a safe environment for drug production, and the residual drug impurities will be cross-contaminated with new drugs, which is far from meeting GMP requirements. Therefore, it is urgent to strengthen the research of online cleaning technology, develop high-quality online cleaning equipment, and optimize the online cleaning process. It is also a focus that China's pharmaceutical enterprises and pharmaceutical machinery and equipment industry need to pay attention.
High-speed and high-quality ultrasonic cleaning equipment to achieve automation

Ultrasonic cleaning technology is widely used in the pharmaceutical industry. Known as the modern cleaning means of ultrasonic cleaning is the use of ultrasonic cavitation effect in the liquid medium, the liquid medium where the mop body and outer surface cleaning, with high quality, labor saving, and other significant characteristics, in the western developed industrial countries has been widely used, and achieved great economic benefits. China has also begun to gradually promote the use of this new technology.
Ultrasonic cleaning equipment using the principle of ultrasonic cleaning, can achieve a comprehensive clean cleaning effect, especially for deep holes, blind holes, concave groove cleaning is the most ideal equipment, does not affect the material and precision of any object. Compared with other cleaning, it has the advantages of high cleaning rate, less residue, short cleaning time, good cleaning effect and energy saving. All cleaning parts that can be immersed in liquid have ultrasonic cleaning effect on it.